| Identification | Back Directory | [Name]
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE | [CAS]
552-54-5 | [Synonyms]
C.I.75700
rhamnacene
NSC 678106
RhaMnacine
RHAMNAZIN(SH)
3,7-DIMETHYLQUERCETIN
7,3'-DiMethylquercetin
3',7-Di-O-Methylquercetin
7,3'-Di-O-methylquercetin
QUERCETIN-3,7-DIMETHYL ETHER
Quercetin 7,3'-DiMethyl Ether
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxychromen-4-one
3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy- | [Molecular Formula]
C17H14O7 | [MDL Number]
MFCD00017426 | [MOL File]
552-54-5.mol | [Molecular Weight]
330.29 |
| Chemical Properties | Back Directory | [Melting point ]
214-215 °C | [Boiling point ]
591.6±50.0 °C(Predicted) | [density ]
1.507±0.06 g/cm3(Predicted) | [form ]
powder | [pka]
6.14±0.40(Predicted) | [BRN ]
338203 | [InChI]
InChI=1S/C17H14O7/c1-22-9-6-11(19)14-13(7-9)24-17(16(21)15(14)20)8-3-4-10(18)12(5-8)23-2/h3-7,18-19,21H,1-2H3 | [InChIKey]
MYMGKIQXYXSRIJ-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=C(O)C(OC)=C2)OC2=CC(OC)=CC(O)=C2C(=O)C=1O |
| Hazard Information | Back Directory | [Uses]
Di-O-methylated flavanol; a polyphenolic metabolite of Rhamnus disperma. | [Definition]
ChEBI: A dimethoxyflavone that is quercetin in which the hydroxy groups at the 3' and 7 positions have been replaced by methoxy groups. | [in vivo]
Rhamnazin (200 mg/kg; i.g.; daily for 25 days) inhibits breast cancer growth and angiogenesis in mice[1].
Rhamnazin (5-20 mg/kg; i.p.; once) shows strong antioxidant and anti-inflammatory properties in the rat acute lung injury model[2]. | Animal Model: | BALB/c nude mice, breast cancer xenograft model[1] | | Dosage: | 200 mg/kg | | Administration: | Intragastric administration, daily for 25 days | | Result: | Dramatically suppressed tumor volumes by 47% compared with the vehicle group. Showed a significant reduction of pVEGFR2Tyr951-positive cells in tumors. Resulted in downregulation of VEGFR2 downstream molecules phosphorylation including MAPK, AKT and STAT3. |
| [IC 50]
VEGFR2: 4.68 μM (IC50) |
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| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
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