| Identification | Back Directory | [Name]
1-Boc-pyrazole-4-boronic acid pinacol ester | [CAS]
552846-17-0 | [Synonyms]
EOS-60399
N-BOC-PYRAZOLE-4-BORONIC ACID PINACOL ESTER
1-BOC- 4-PYRAZOLEBORONIC ACID PINACOL ESTER
N-Boc-pyrazole-4-boronic acid pinaxcol ester
1-BOC-1H-pyrazol-4-boronic acid pinacol ester
1-N-Boc-pyrazole-4-boronic acid pinacol ester
1-BOC-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER
1-tert-Butoxycarbonyl-4-1H-pyrazoleboronic acid
1-Boc-pyrazole-4-boronic acid pinacol ester 97%
1-BOC-PYRAZOLE-4-BORONIC ACID PINACOL ESTER, 97%
1H-Pyrazole-4-boronic acid, pinacol ester, N1-BOC protected
1-TERT-BUTOXYCARBONYL-4-1H-PYRAZOLBORONIC ACID PINACOL ESTER
1-BOC-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRAZOLE
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-Bocpyrazole
N-Boc-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-pyrazole
1-TERT-BUTOXYCARBONYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER
1-TERT-BUTOXYCARBONYL-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER
1-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole ,97%
(1-(TERT-BUTOXYCARBONYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate
tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate
1-tert-Butoxycarbonyl-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrazole
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylic acid ter
tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-pyrazolecarboxylate
1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
TERT-BUTYL 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE CARBOX., 97%
tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate
1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylic acid tert-butyl e
4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
tert-butyl 4-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boryl)-1H-pyrazole-1-carboxylate
4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-carboxylic acid tert-butyl ester
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylic acid tert-butyl ester
1,1-dimethylethyl ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-Pyrazole-1-carboxylic acid
1H-Pyrazole-1-carboxylic acid,4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-,1,1-dimethylethyl ester
1-Boc-pyrazole-4-boronic acid pinacol ester
1-tert-Butoxycarbonyl-1H-pyrazole-4-boronic acid pinacol ester
1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate
1-Boc-4-pyrazoleboronic acid pinacol ester, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-Boc-pyrazole, tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-pyrazolecarboxylate | [Molecular Formula]
C14H23BN2O4 | [MDL Number]
MFCD05663873 | [MOL File]
552846-17-0.mol | [Molecular Weight]
294.16 |
| Chemical Properties | Back Directory | [Appearance]
white to beige crystalline powder | [Melting point ]
82-86 °C(lit.)
| [Boiling point ]
387.9±34.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator (+4°C) | [solubility ]
soluble in Methanol | [form ]
Crystalline Powder | [pka]
-1.20±0.12(Predicted) | [color ]
White to beige | [Water Solubility ]
insoluble | [InChI]
InChI=1S/C14H23BN2O4/c1-12(2,3)19-11(18)17-9-10(8-16-17)15-20-13(4,5)14(6,7)21-15/h8-9H,1-7H3 | [InChIKey]
IPISOFJLWYBCAV-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)C=C(B2OC(C)(C)C(C)(C)O2)C=N1 |
| Hazard Information | Back Directory | [Chemical Properties]
white to beige crystalline powder | [Uses]
1-Boc-pyrazole-4-boronic Acid Pinacol Ester is used as a reagent in the synthesis of several inhibitors including thieno[3,2-c]pyridin-4-amines which are a novel series of Bruton’s tyrosine kinase (BTK) inhibitors which can be used in drug design. | [Synthesis]
4-Pyrazoleboronic acid pinacol ester (1.16 g, 6.0 mmol) and di-tert-butyl dicarbonate (1.58 g, 7.2 mmol) were used as raw materials and dissolved in dichloromethane (40 mL). A catalytic amount of 4-dimethylaminopyridine (102 mg, 0.84 mmol) was added and the reaction was stirred at room temperature for 4 hours. After completion of the reaction, water was added to the reaction system and extracted with ethyl acetate. The organic phase was washed with saturated aqueous sodium chloride solution and then the solvent was removed by rotary evaporation to give the crude product 1-Boc-pyrazole-4-boronic acid pinacol ester (1.5 g, 85% yield). | [References]
[1] Patent: CN103936728, 2016, B. Location in patent: Paragraph 0177; 0203; 0204; 0205
[2] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 68
[3] Patent: WO2018/154466, 2018, A1. Location in patent: Paragraph 001162; 001164; 001165
[4] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 58
[5] Patent: WO2004/56727, 2004, A2. Location in patent: Page 97 |
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