| Identification | Back Directory | [Name]
Herbicidin A | [CAS]
55353-31-6 | [Synonyms]
Herbicidin
Herbicidin A
(11R)-11-C-(6-Amino-9H-purin-9-yl)-2,6:8,11-dianhydro-10-O-methyl-4-O-[(E)-1-oxo-2-(hydroxymethyl)-2-butenyl]-7-deoxy-α-L-ido-D-lyxo-5-undecoulo-5,9-pyranosonic acid methyl ester
D-arabino-α-L-ido-7-Undeculo-7,3-pyranose-1,4-furanuronic acid, 1-(6-amino-9H-purin-9-yl)-6,10-anhydro-1,5-dideoxy-2-O-methyl-, methyl ester, 8-[(2E)-2-(hydroxymethyl)-2-butenoate], (7R)- | [Molecular Formula]
C23H29N5O11 | [MDL Number]
MFCD01677176 | [MOL File]
55353-31-6.mol | [Molecular Weight]
551.5 |
| Chemical Properties | Back Directory | [Boiling point ]
826.5±75.0 °C(Predicted) | [density ]
1.78±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A solid | [pka]
10.17±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Herbicidin A is an adenine nucleoside antibiotic originally isolated from S. saganonensis that exhibits herbicidal activity, particularly against dicotyledonous plants. It prevents rice seed germination (MIC = 6.25 μg/ml) and completely protects young rice plants from X. oryzae-induced leaf blight when applied at 100 ppm. In HEK293 cells, herbicidin A inhibits TNF-α-induced NF-κB activity and induces cytotoxicity (IC50s = 1.8 and 2.7 μM, respectively). | [Uses]
Herbicidin A is a chemical with antibacterial and herbicidal activity. | [Uses]
Herbicidin A is the major analogue of a family of adenosine nucleosides containing a complex tricyclic saccharide originally isolated from Streptomyces saganonensis, reported by researchers at Sankyo in 1976. Hebicidin A is a potent herbicide with selective activity against dicotyledonous plants. The mode of action and broader pharmacology of herbicidin A has received little attention due to its restricted availability. |
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