| Identification | Back Directory | [Name]
[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate | [CAS]
5542-28-9 | [Synonyms]
Ap4A
AppppA
Diadenosine tetraphoshate
Diadenosine tetraphosphate
5',5'''-Diadenosine tetraphosphate
P(1),P(4)-bis(5'-adenosyl) tetraphosphate
Diphosphoric acid P1,P2-di(5'-adenylyl) ester
5'-O-[[[(5'-Adenylyl)oxyphosphonyl]oxyphosphonyl]oxyphosphonyl]adenosine
Adenosine 5'-(pentahydrogen tetraphosphate), P'''→5'-ester with adenosine
[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate | [Molecular Formula]
C20H28N10O19P4 | [MDL Number]
MFCD00871355 | [MOL File]
5542-28-9.mol | [Molecular Weight]
836.39 |
| Hazard Information | Back Directory | [Uses]
Ap4A (P1,P4-Di-(adenosine-5')-tetraphosphate) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A induces apoptosis[1][2]. | [Definition]
ChEBI: A diadenosyl tetraphosphate compound having the two 5'-adenosyl residues attached at the P1- and P4-positions. | [References]
[1] Yu J, et al. Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells. Nat Commun. 2019 Oct 11;10(1):4664. DOI:10.1038/s41467-019-12710-8
[2] Vartanian A, et al. Ap4A induces apoptosis in human cultured cells. FEBS Lett. 1999 Jul 30;456(1):175-80. DOI:10.1016/s0014-5793(99)00956-4 |
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