| Identification | Back Directory | [Name]
2-[1-[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonyl]-1H-indol-3-yl]ethylamine Hydrochloride | [CAS]
554403-08-6 | [Synonyms]
SAX-187 hydrochloride
2-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylindol-3-yl]ethanamine
hydrochloride 1H-Indole-3-ethanamine, 1-((6-chloroimidazo((2,1-b)thiazol-5-yl)sulfonyl)-, hydrochloride (1:1) | [Molecular Formula]
C15H14Cl2N4O2S2 | [MDL Number]
MFCD29907475 | [MOL File]
554403-08-6.mol | [Molecular Weight]
417.32 |
| Hazard Information | Back Directory | [Uses]
2-[1-[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonyl]-1H-indol-3-yl]ethylamine Hydrochloride is the HCl salt of 2-[1-[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonyl]-1H-indol-3-yl]ethylamine which is a selective 5-HT6 receptor agonist. It has been proven to have antidepressant and anxiolytic effects on rats suggesting its usefulness as a potential antidepressant. | [in vivo]
Acute administration of WAY-181187 (3-30 mg/kg, s.c.) hydrochloride significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 (30 mg/kg, s.c.) hydrochloride produces modest yet significant decreases in cortical dopamine and 5-HT levels[1]. | Animal Model: | Adult male Sprague-Dawley rats weighing 280-350 g[1] | | Dosage: | 3, 10, or 30 mg/kg | | Administration: | Acute dministered by s.c. | | Result: | Significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.
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| [IC 50]
5-HT6 Receptor: 2.2 nM (Ki); 5-HT6 Receptor: 6.6 nM (EC50) |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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