| Identification | Back Directory | [Name]
5-vinyl-uridine | [CAS]
55520-64-4 | [Synonyms]
5-vinyl-uridine
5-Ethenyluridine
Uridine, 5-ethenyl-
5-Vinyl-uridine (5-VU) | [Molecular Formula]
C11H14N2O6 | [MDL Number]
MFCD30748949 | [MOL File]
55520-64-4.mol | [Molecular Weight]
270.24 |
| Chemical Properties | Back Directory | [Melting point ]
250-255 °C (decomp) | [density ]
1.641±0.06 g/cm3(Predicted) | [solubility ]
DMSO, methanol | [pka]
9.07±0.10(Predicted) | [Appearance]
white solid |
| Hazard Information | Back Directory | [Description]
5-Vinyl-uridine (VU) is a uridine derivative with a terminal alkene group that can be used for monitoring and investigating RNA transcription in cells instead of 5-ethynyl-uridine (EU).
VU is readily taken up by living cells and incorporated by RNA polymerases into de novo RNA instead of endogenous uridine, but not into DNA [1]. VU-labeled nascent cellular RNA can be detected quickly and with high sensitivity via inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA) between the vinyl group and fluorescently or biotin-labeled tetrazines.
Labeled RNA can be detected with different cell transcriptional levels estimation methods, e.g., fluorescent microscopy or flow cytometry.
[1] Liu H.S. et al. A Nucleoside Derivative 5-Vinyluridine (VrU) for Imaging RNA in Cells and Animals. Bioconjug.Chem. 2019. 30(11). 2958-2966. |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList1701258/0_EN.htm |
| Company Name: |
Enzo Biochem Inc
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| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
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