| Identification | Back Directory | [Name]
AV-1101 | [CAS]
55648-39-0 | [Synonyms]
4OHOPB
4OH-OPB
AV 1101
AV-1101
4OH OPB
AV 1101,AV1101
4-Hydroxyoxyphenbutazone
3,5-Pyrazolidinedione, 4-butyl-4-hydroxy-1-(4-hydroxyphenyl)-2-phenyl- | [Molecular Formula]
C19H20N2O4 | [MOL File]
55648-39-0.mol | [Molecular Weight]
340.37 |
| Chemical Properties | Back Directory | [Melting point ]
177-179 °C(Solv: benzene (71-43-2)) | [Boiling point ]
524.6±60.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [pka]
10.03±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard agents. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive agent and has the potential for rheumatoid arthritis research[1][2]. | [References]
[1] Ben Gold, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. DOI:10.1073/pnas.1214188109
[2] Anja Ten Brinke, et al. 4-Hydroxy-oxyphenbutazone is a potent inhibitor of cytokine production. Eur Cytokine Netw. 2005 Jun;16(2):144-51. PMID:15941686 |
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