| Identification | Back Directory | [Name]
2-Thiazolemethanamine | [CAS]
55661-33-1 | [Synonyms]
2-Thiazolemethamine
2-AMINOMETHYLTHIAZOLE
2-Thiazolemethanamine
thiazol-2-ylMethanaMine
(2-Thiazolyl)methylamine
Thiazol-2-yl-methylamine
C-THIAZOL-2-YL-METHYLAMINE
(Thiazole-2-ylMethyl)aMine
2-Aminomethyl-1,3-thiazole
2-(AMinoMethyl)thiazole 97%
1,3-thiazol-2-ylmethanamine
2-Aminomethylthiazoledihydrochloride
2-AMINOMETHYLTHIAZOLE HYDROCHLORIDE 98%
1,3-thiazol-2-ylMethanaMine hydrochloride
C-Thiazol-2-Yl-Methylamine dihydrochloride
1,3-thiazol-2-ylmethylamine dihydrochloride
(1,3-thiazol-2-ylmethyl)amine(SALTDATA: 2HCl)
Thiazol-2-yl-methylamine dihydrochloride≥ 98% (HPLC) | [Molecular Formula]
C4H6N2S | [MDL Number]
MFCD02854204 | [MOL File]
55661-33-1.mol | [Molecular Weight]
114.17 |
| Chemical Properties | Back Directory | [Melting point ]
180-185°C | [Boiling point ]
36 °C | [density ]
1.204 g/mL at 25 °C | [refractive index ]
n20/D1.569 | [Fp ]
104℃ | [storage temp. ]
2-8°C(protect from light) | [form ]
liquid | [pka]
7.24±0.40(Predicted) | [color ]
Yellow-green | [InChI]
1S/C4H6N2S/c5-3-4-6-1-2-7-4/h1-2H,3,5H2 | [InChIKey]
JOZSYOPADROCMP-UHFFFAOYSA-N | [SMILES]
NCc1nccs1 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white to cream color solid | [Uses]
(2-Thiazolyl)methylamine is a useful compound in the preparation of cephalosporins
| [Synthesis]
The general procedure for the synthesis of 2-thiazole-methyl-amine from the compound (CAS: 171268-82-9) and water (electrophoretic grade) is as follows:
1. Preparation of GG1 thiazol-2-yl-methylamine azide: triphenylphosphine (2.08 g, 7.9 mmol) was added to a solution of 2-azidomethyl-thiazole (1.11 g, 7.9 mmol) in tetrahydrofuran (THF, 20 mL).
2. Reduction reaction: after 1 h, water (214 μL) and ammonium hydroxide sol (0.5 mL) were added sequentially.
3. Post-treatment: The reaction mixture was stirred overnight and subsequently concentrated under vacuum and purified by fast chromatography (eluent: 5% methanol/dichloromethane) to give the title product 2-thiazolemethanamine as a tan oil (645 mg, 72% yield).
4. The product was characterized by 1H NMR (250 MHz, CDCl3) δ 7.7 (d, 1H, J = 2.0 Hz); 7.25 (d, 1H, J = 2.0 Hz); 4.2 (s, 2H); 1.7 (bs, 2H). | [References]
[1] Patent: US5939398, 1999, A
[2] Patent: US5698526, 1997, A |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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