| Identification | Back Directory | [Name]
Capuride | [CAS]
5579-13-5 | [Synonyms]
Capuride
McN-X-94
NSC27690
NSC-27690
NSC-27178
1-(2-Ethyl-3-methylvaleryl)urea
N-carbamoyl-2-ethyl-3-methyl-valeramide
N-carbamoyl-2-ethyl-3-methyl-pentanamide
N-aminocarbonyl-2-ethyl-3-methyl-pentanamide
Pentanamide, N-(aminocarbonyl)-2-ethyl-3-methyl- | [Molecular Formula]
C9H18N2O2 | [MDL Number]
MFCD00867536 | [MOL File]
5579-13-5.mol | [Molecular Weight]
186.25 |
| Hazard Information | Back Directory | [Uses]
Sedative-
hypnotic. | [Definition]
ChEBI: Capuride is an N-acylurea in which the acyl substituent is 2-ethyl-3-methylpentanoyl. A monoureide sedative, it has a duration of hypnotic effect similar to that of the short-acting barbiturates. It has a role as a sedative. | [Brand name]
Pacinox (Ortho-McNeil). | [in vivo]
Capuride (VPA, 38-107 mg/kg p.o.) shows anticonvulsant activity in MES and scMet induced seizures rats[2].
Capuride (p.o., rats) shows neurotoxicity with an ED50 of 232 mg/kg[2].
Capuride (49-71 mg/kg, i.p.) shows anticonvulsant activity in 6 Hz Psychomotor seizure mice[2].
| Animal Model: | Electrically (MES) and chemically (scMet) induced seizures in rats[2] | | Dosage: | 38-107 mg/kg | | Administration: | Oral administration (p.o.) | | Result: | ED50s: 54 mg/kg (MES model), 77 mg/kg (scMet model). |
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