| Identification | Back Directory | [Name]
bromchlorenone | [CAS]
5579-85-1 | [Synonyms]
NSC-24970
bromchlorenone
BROMOCHLORENONE
6-Bromo-5-chlorobenzo[d]oxazol-2(3H)
6-Bromo-5-chlorobenzoxazol-2(3H)-one
6-Bromo-5-chloro-3H-benzooxazol-2-one
2(3H)-Benzoxazolone, 6-bromo-5-chloro-
6-Bromo-5-chloro-3H-1,3-benzoxazol-2-one
6-bromo-5-chlorobenzo[d]oxazol-2(3H)-one | [EINECS(EC#)]
226-967-0 | [Molecular Formula]
C7H3BrClNO2 | [MOL File]
5579-85-1.mol | [Molecular Weight]
248.46 |
| Hazard Information | Back Directory | [Uses]
Anti-infective, topical. | [Synthesis]
2-Amino-5-bromo-4-chlorophenol (Intermediate 7, 8.4 g, 37.8 mmol) and N,N'-carbonyldiimidazole (12.2 g, 75.6 mmol) were used as raw materials and reacted in THF (250 mL) for 3 hours at 80 °C. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography (200-400 mesh, 100 g) with petroleum ether/ethyl acetate as eluent (gradient from 9:1 to 5:1) to afford 6-bromo-5-chlorobenzo[d]oxazol-2(3H)-one as an orange solid (7.7 g, 82% yield).LCMS (Method A): retention time 1.49 min, molecular ion peak m/z 248 /250 [M+H]+. | [References]
[1] Patent: WO2015/91647, 2015, A1. Location in patent: Page/Page column 42 |
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