| Chemical Properties | Back Directory | [Boiling point ]
435.4±55.0 °C(Predicted) | [density ]
1.727±0.06 g/cm3(Predicted) | [solubility ]
DMSO: 2 mg/mL, clear | [form ]
Solid | [pka]
6.56±0.48(Predicted) | [color ]
White to off-white | [InChIKey]
AIZXCKZVUXCHAP-UHFFFAOYSA-N | [SMILES]
O=S(NC1=CC=CC=C1)(C2=CC=C(S2)Br)=O |
| Hazard Information | Back Directory | [Description]
ES9-17 is a novel Clathrin-mediated endocytosis (CME) inhibitor, targeting clathrin heavy chain (CHC). | [Uses]
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings[1][2]. | [References]
[1] Dejonghe W, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15(6):641-649. DOI:10.1038/s41589-019-0262-1
[2] Huang L, et al. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. Curr Opin Plant Biol. 2019 Dec;52:106-113. DOI:10.1016/j.pbi.2019.07.004 |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
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