| Identification | Back Directory | [Name]
1,3-Benzenediol, 4-chloro-6-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]- | [CAS]
558638-15-6 | [Synonyms]
1,3-Benzenediol, 4-chloro-6-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]- | [Molecular Formula]
C17H15ClN2O3 | [MOL File]
558638-15-6.mol | [Molecular Weight]
330.77 |
| Hazard Information | Back Directory | [Uses]
Antibacterial agent 241 is a histidine kinase (HK) inhibitor, with IC50 values of 14 μM and 238 μM for CckA and PhoQ, respectively. Antibacterial agent 241 shows moderate antibacterial activity against E. coli DC2, Bacillus cereus, and Bacillus subtilis, with a MIC range of 12-74 μg/mL[1]. | [References]
[1] Fernandez-Ciruelos B, et al. Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity. Microbiol Spectr. 2024 Aug 6;12(8):e0014624. DOI:10.1128/spectrum.00146-24 |
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