| Identification | Back Directory | [Name]
2-AMINO-3,4,5-TRICHLOROPYRIDINE | [CAS]
55933-91-0 | [Synonyms]
3,4,5-Trichloropyridin-2-amine
3,4,5-trichloro-2-pyridinamine
2-AMINO-3,4,5-TRICHLOROPYRIDINE
2-Pyridinamine, 3,4,5-trichloro-
2-AMINO-3,4,5-TRICHLOROPYRIDINE ISO 9001：2015 REACH | [Molecular Formula]
C5H3Cl3N2 | [MDL Number]
MFCD08705655 | [MOL File]
55933-91-0.mol | [Molecular Weight]
197.45 |
| Chemical Properties | Back Directory | [Boiling point ]
272.7±35.0 °C(Predicted) | [density ]
1.634±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
2.02±0.10(Predicted) | [Appearance]
off-white solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3,4,5-trichloropyridin-2-amine from 2-amino-4-chloropyridine: 2-amino-4-chloropyridine (5.0 g, 0.04 mol) was dissolved in concentrated hydrochloric acid (20 mL) and the solution was cooled to 0 °C in an ice bath. Hydrogen peroxide (8.1 mL, 0.08 mol, 32% aqueous solution) was slowly added to the cooled solution, followed by gradual warming of the reaction mixture to room temperature and continuous stirring for 4 hours. Upon completion of the reaction, the mixture was poured into 100 mL of water and the pH was adjusted to 8 (litmus base) by addition of solid sodium carbonate, followed by extraction with ethyl acetate (3 x 50 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, and the filtrate was filtered and concentrated to give a yellow solid product. Finally, purification by ethanol recrystallization afforded 6.3 g (80% yield) of the target compound 3,4,5-trichloropyridin-2-amine as a white solid with a melting point of 160-162 °C. | [References]
[1] Patent: US6214801, 2001, B1 |
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