| Identification | Back Directory | [Name]
4-METHYLPYRAZOLE HYDROCHLORIDE | [CAS]
56010-88-9 | [Synonyms]
FOMEPIZOLE HYDROCHLORIDE
4-METHYLPYRAZOLE HYDROCHLORIDE
Fomepizole/FomepizolechlorideHCl
4-Methyl-1H-pyrazole hydrochloride
4-Methylpyrazole hydrochloride alcohol dehydrogenase inhibitor | [Molecular Formula]
C4H7ClN2 | [MDL Number]
MFCD00012707 | [MOL File]
56010-88-9.mol | [Molecular Weight]
118.56 |
| Chemical Properties | Back Directory | [Melting point ]
157-159 °C | [storage temp. ]
2-8°C | [solubility ]
methanol: 100mg/mL, clear, colorless to yellow | [form ]
powder | [color ]
Purple to purplish red | [biological source]
synthetic (organic) | [InChI]
1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H | [InChIKey]
PUCXJHNDMYZOHG-UHFFFAOYSA-N | [SMILES]
Cl.Cc1cn[nH]c1 |
| Hazard Information | Back Directory | [Uses]
4-Methylpyrazole hydrochloride has been used:
- as a cytochrome P450 2E1 inhibitor
- as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
- to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells
| [Biochem/physiol Actions]
4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models. | [in vivo]
Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice[4] | Animal Model: | Male CD-1 mice weighing 18-25 g[4] | | Dosage: | 25 mg/kg | | Administration: | IP; single dose | | Result: | Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50). |
| [IC 50]
CYP2E1 |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
SynAsst Chemical.
|
| Tel: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|