| Identification | Back Directory | [Name]
3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE | [CAS]
562823-84-1 | [Synonyms]
MDM2 Inhibitor
TRANS-4-IODO,4'-BORANYL-CHALCONE
MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem
3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE
3-(4-IODO-PHENYL)-1-(4''- BORANYL-PHENYL)-PROP-2-ENONE (FOR R&D ONLY)
Boronic acid, B-[4-[(2E)-3-(4-iodophenyl)-1-oxo-2-propen-1-yl]phenyl]- | [Molecular Formula]
C15H12BIO3 | [MDL Number]
MFCD06798340 | [MOL File]
562823-84-1.mol | [Molecular Weight]
377.97 |
| Hazard Information | Back Directory | [Uses]
TLBC, a boronic-chalcone derivative, shows a dose-dependent inhibition with IC50 values of 5.5-25.5 μM in various glioma cell lines. TLBC induces apoptosis independent of changes to the tumor suppressor p53[1]. | [Definition]
ChEBI: [4-[3-(4-iodophenyl)prop-2-enoyl]phenyl]boronic acid is a member of chalcones. | [General Description]
A cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC50 = 10 μM for MDA-MB-435, 8.8 μM for MDA-MB-231, and 7 μM for Wt-MCF7) compared to normal breast cell lines (IC50 = 75 μM for MCF-10A and 63 μM for MCF-12A). | [Biochem/physiol Actions]
Cell permeable: yes | [References]
[1] Takashi Sasayama, et al. Trans-4-lodo,4'-boranyl-chalcone induces antitumor activity against malignant glioma cell lines in vitro and in vivo. J Neurooncol. 2007 Nov;85(2):123-32. DOI:10.1007/s11060-007-9395-2 |
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Sigma-Aldrich
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