| Identification | Back Directory | [Name]
Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- | [CAS]
56363-81-6 | [Synonyms]
Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)-
1-(5-hydroxybenzo[b]thiophen-2-yl)ethanone | [Molecular Formula]
C10H8O2S | [MOL File]
56363-81-6.mol | [Molecular Weight]
192.23 |
| Chemical Properties | Back Directory | [Melting point ]
190-191 °C(Solv: chloroform (67-66-3)) | [Boiling point ]
375.4±22.0 °C(Predicted) | [density ]
1.344±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 50mg/mL | [form ]
powder | [pka]
9.03±0.40(Predicted) | [color ]
yellow | [SMILES]
O=C(C)C1=CC2=CC(O)=CC=C2S1 |
| Hazard Information | Back Directory | [Uses]
A cell permeable 5-hydroxybenzothiophenylethanone that acts as a dual inhibitor of Cdc2-like kinase 1 (Clk1; IC50 = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC50 = 200 and 100 nM, respectively). Also inhibits Clk4 with high potency. Exhibits much reduced inhibitory effect on Haspin ( IC50 = 800 nM) and has much reduced inhibitory effect on other kinases even at higher concentration (~ 5 µM). Causes a complete disappearance of incomplete and alternatively spliced transcripts and is shown to enhance the generation of the mature Clk1 mRNA splicing product (EC50 = 8.9 µM) in cells.
A cell permeable, dual inhibitor of Cdc2-like kinase 1 (Clk1; IC₅₀ = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC₅₀ = 200 and 100 nM, respectively). | [Biological Activity]
Cell permeable: yes''Primary Target
DYRK/CLK |
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