| Identification | Back Directory | [Name]
Capillarisin | [CAS]
56365-38-9 | [Synonyms]
Capillaris
CAPILLARISIN
CAPILLARISIN(RG)
CAPILLARISIN hplc
Capillarisin std.
Capillarisin Standard
Capillarisin USP/EP/BP
5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one
5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one
5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-1-benzopyran-4-one
2-(4-Hydroxyphenoxy)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one
5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy- | [Molecular Formula]
C16H12O7 | [MDL Number]
MFCD00017728 | [MOL File]
56365-38-9.mol | [Molecular Weight]
316.26 |
| Chemical Properties | Back Directory | [Melting point ]
approximate 225℃ (dec.) | [Boiling point ]
582.6±50.0 °C(Predicted) | [density ]
1.551±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
6.37±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3]. | [Definition]
ChEBI: Capillarisin is a member of coumarins. | [in vivo]
Capillarisin (20 and 80 mg/kg; i.p.; 1 hour) pretreatment strongly inhibits NF-κB mediated genes (iNOS, COX-2)[4].
Capillarisin significantly reduces the plasma leading nitrite production. Capillarisin markedly suppresses the adenosine 5'-triphosphate (ATP) in plasma and substance P in CFA-induced paw tissue[4]. | Animal Model: | ICR mice[4] | | Dosage: | 20 and 80 mg/kg | | Administration: | I.p.; 1 hour | | Result: | Pretreatment strongly inhibited NF-κB mediated genes (iNOS, COX-2).
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| [target]
TLR | NF-kB | MAPK | STAT | TNF-α | IL Receptor | NO | PGE | AP-1 | ERK | NOS | COX | MMP(e.g.TIMP) | VEGFR | JNK | Bcl-2/Bax | [References]
[1] Peng G, et al. Capillarisin exerts antiasthmatic activity in neonatal rats via modulating the matrix remodeling. Pak J Pharm Sci. 2020;33(4(Supplementary)):1907-1915. PMID:33612476
[2] Komiya T, et al. Capillarisin, a Constituent from Artemisiae Capillaris Herba. Chemical and Pharmaceutical Bulletin, 1975
[3] Zhao T, Wang Q. Capillarisin protects SH-SY5Y cells against bupivacaine-induced apoptosis via ROS-mediated PI3K/PKB pathway. Life Sci. 2020;259:118279. DOI:10.1016/j.lfs.2020.118279
[4] Khan S, et al. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. J Ethnopharmacol. 2014;152(3):478-486. DOI:10.1016/j.jep.2014.01.028 |
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