| Identification | Back Directory | [Name]
MPC | [CAS]
56525-42-9 | [Synonyms]
MPC
butan-2-ylcarbonate
methyl propyl carbonate
Carbonic acid, methyl propyl ester | [Molecular Formula]
C5H10O3 | [MOL File]
56525-42-9.mol | [Molecular Weight]
118.13 |
| Chemical Properties | Back Directory | [Boiling point ]
125 °C(Press: 630 Torr) | [density ]
0.976±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 2-aminobenzimidazole, propyl carbonate and methylpropyl carbonate from n-propanol and compounds (CAS:162976-69-4) is as follows: amide-containing compounds having a (benzo)imidazole-2-yl group can be subjected to catalytic directional cleavage reactions with alcohol nucleophilic reagents in the presence of a metal catalyst. Specific embodiments are described in Scheme ES: using 10.0 mol% Zn(OAc)2-2H2O as a catalyst, 1.0 equivalent of ACDG-NH-C(O)-R3 (21d), and 30.0 equivalents of propanol (under sealed conditions) for a reaction time of 24 hr; wherein R is a 1H-benzo[d]imidazol-2-yl group, and R3 is an OMe. Reaction products The yields were determined by NMR analysis using TMB as an internal standard: 0% for unreacted 21d, 61% for 2-aminobenzimidazole (20d), 40% for methylpropyl carbonate (14c) and 22% for dipropyl carbonate (14d). | [References]
[1] Patent: WO2017/46133, 2017, A1. Location in patent: Page/Page column 58; 59 |
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