56542-65-5

56542-67-7

62-53-3

56542-65-5

GENERAL METHOD: A mixture of 3-cyanobenzenesulfonyl chloride (605 mg, 3 mmol), aniline (3.3 mmol) and pyridine (736 mg, 9.3 mmol) was reacted at room temperature in anhydrous dichloromethane (40 mL) with stirring overnight. Upon completion of the reaction, the solvent was evaporated under reduced pressure and the resulting crude product was purified by fast column chromatography (eluent: dichloromethane) or by recrystallization from ethyl acetate/hexane mixed solvent or toluene to afford the target product 3-cyano-N-phenylbenzenesulfonamide.