| Identification | Back Directory | [Name]
1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl- | [CAS]
56563-17-8 | [Synonyms]
PluriSIn #2
1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl- | [Molecular Formula]
C11H8FN3O3 | [MDL Number]
MFCD00703242 | [MOL File]
56563-17-8.mol | [Molecular Weight]
249.2 |
| Chemical Properties | Back Directory | [Melting point ]
223 °C | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light, stored under nitrogen | [solubility ]
DMSO: 5 mg/mL (20.06 mM) | [form ]
Solid | [pka]
6.88±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1]. | [IC 50]
topoisomerase II alpha | [storage]
4°C, protect from light, stored under nitrogen | [References]
[1] Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33(3):1013-9. DOI:10.1002/stem.1888 |
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