| Identification | Back Directory | [Name]
2-Naphthaleneacetic acid, α-ethyl-6-methoxy- | [CAS]
56600-73-8 | [Synonyms]
MDK-0738
AKR1C3 IN 14a
AKR1C3-IN-14a
2-Naphthaleneacetic acid, α-ethyl-6-methoxy- | [Molecular Formula]
C15H16O3 | [MOL File]
56600-73-8.mol | [Molecular Weight]
244.29 |
| Hazard Information | Back Directory | [Description]
MDK-0738, also known as AKR1C3-IN-14a, is a potent and selective aldo-keto reductase 1C3 inhibitor. The name MDK-0738 uses the last four digits of the CAS registry number for this compound. MDK-0738 displays selectivity for AKR1C3 over other AKR1C enzymes and COX. | [Uses]
AKR1C2/3-IN-2 is a potential AKR1C3 inhibitor with selective AKR1C3 activity. AKR1C2/3-IN-2 is able to block AKR1C3-mediated testosterone (T) production and PSA induction, affecting the endocrine activity of prostate cancer cells. AKR1C2/3-IN-2 shows selectivity over other AKR1C enzymes, indicating its potential application in inhibiting drug-resistant prostate cancer. AKR1C2/3-IN-2 has no inhibitory activity against COX isomerases, further emphasizing its specificity as a prostate cancer inhibitory compound[1]. | [References]
[1] Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor |
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