| Identification | Back Directory | [Name]
STE-MPKKKPTPIQLNP-NH2 | [CAS]
566872-15-9 | [Synonyms]
STE-MEK1(13)
STE-MPKKKPTPIQLNP-NH2
STEARYL-MEK-1 DERIVED PEPTIDE INHIBITOR 1, AMIDE
ERK ACTIVATION INHIBITOR PEPTIDE I, CELL-PERMEABLE
STE-MET-PRO-LYS-LYS-LYS-PRO-THR-PRO-ILE-GLN-LEU-ASN-PRO-NH2 | [Molecular Formula]
C86H153N19O17S | [MDL Number]
MFCD04974162 | [MOL File]
566872-15-9.mol | [Molecular Weight]
1757.32 |
| Chemical Properties | Back Directory | [Boiling point ]
1814.130±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.196±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
-20°C | [solubility ]
water: 1 mg/mL || DMSO: 5 mg/mL | [form ]
lyophilized solid | [pka]
13.329±0.46(predicted) | [color ]
white | [Water Solubility ]
water: 1mg/mL
DMSO: 5mg/mL | [Sequence]
{Ste}-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2 |
| Hazard Information | Back Directory | [Uses]
STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH ) is a cell permeable ERK1/2 inhibitor (IC50: 13-30 μM). STE-MEK1(13) inhibits ERK1/2 phosphorylation[1][2]. | [Biological Activity]
Cell permeable: yes''Primary Target
MEK''Product does not compete with ATP.''Reversible: yes | [References]
[1] Li G, et al. A novel cellular survival factor--the B2 subunit of vacuolar H+-ATPase inhibits apoptosis. Cell Death Differ. 2006 Dec;13(12):2109-17. DOI:10.1038/sj.cdd.4401970
[2] Whiteman M, et al. Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Osteoarthritis Cartilage. 2006 May;14(5):460-70. DOI:10.1016/j.joca.2005.11.002 |
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| Company Name: |
Fuan Bio
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15002819872 |
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fuanbio.com |
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