| Identification | Back Directory | [Name]
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT | [CAS]
56932-43-5 | [Synonyms]
NAPHTHYLAZOXINE S
NAPHTHYLAZOXINE 6S
nsc-87877 disodium salt
NAPHTHYLAZOXINE S DISODIUM SALT
7-(6-Sulfo-2-naphthylazo)-8-hydroxyquinoline-5-sulfonicacid,disodiumsalt
8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-5-quinolinesulfonicacidisodium
7-(6-SULFO-2-NAPHTHYLAZO)-8-HYDROXYQUINOLINE-5-SULFONIC ACID SODIUM SALT
disodium 8-hydroxy-7-[(6-sulphonato-2-naphthyl)azo]quinoline-5-sulphonate
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
8-Hydroxy-7-[(6-sulfo-2-naphthalenyl)-azo]-5-quinolinesulfonic acid disodiu
8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-5-quinolinesulfonic acid disodium
8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt,98%
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5- QUINOLINESULFONIC ACID DISODIUM SALT 98%
5-Quinolinesulfonicacid,8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-,disodiumsalt
8-Hydroxy-7-(6-sodiooxysulfonyl-2-naphtylazo)quinoline-5-sulfonic acid sodium salt | [EINECS(EC#)]
260-449-5 | [Molecular Formula]
C19H11N3Na2O7S2 | [MDL Number]
MFCD00041863 | [MOL File]
56932-43-5.mol | [Molecular Weight]
503.42 |
| Hazard Information | Back Directory | [Chemical Properties]
dark red to red-brown powder | [Uses]
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2]. | [Biological Activity]
Cell permeable: yes''Primary Target
SHP1/2 PTPase''Product does not compete with ATP.''Reversible: no''Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatasesrespectively | [in vivo]
NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3].
| Animal Model: | Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3].
| | Dosage: | 30?mg/kg. | | Administration: | IP once daily for 15 days. | | Result: | Significantly inhibited NB tumor growth. |
| [References]
[1] Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. DOI:10.1124/mol.106.025536
[2] Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. DOI:10.1016/j.bbrc.2009.02.069
[3] Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. DOI:10.1038/cddis.2015.207 |
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https://www.bocsci.com |
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Energy Chemical
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http://www.energy-chemical.com |
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