| Identification | Back Directory | [Name]
PEN (rat) | [CAS]
569364-13-2 | [Synonyms]
PEN (rat)
L-Valine, L-alanyl-L-valyl-L-α-aspartyl-L-glutaminyl-L-α-aspartyl-L-leucylglycyl-L-prolyl-L-α-glutamyl-L-valyl-L-prolyl-L-prolyl-L-α-glutamyl-L-asparaginyl-L-valyl-L-leucylglycyl-L-alanyl-L-leucyl-L-leucyl-L-arginyl- | [Molecular Formula]
C102H169N27O33 | [MDL Number]
MFCD31544502 | [MOL File]
569364-13-2.mol | [Molecular Weight]
2301.63 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [form ]
Solid | [color ]
White to off-white | [Sequence]
Ala-Val-Asp-Gln-Asp-Leu-Gly-Pro-Glu-Val-Pro-Pro-Glu-Asn-Val-Leu-Gly-Ala-Leu-Leu-Arg-Val |
| Hazard Information | Back Directory | [Uses]
PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1]. | [References]
[1] Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891. DOI:10.1021/acschemneuro.8b00559
[2] Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43. DOI:10.1126/scisignal.aad0694 |
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