| Identification | Back Directory | [Name]
Flupirtine | [CAS]
56995-20-1 | [Synonyms]
D-9998
Katadolon
FLUPIRTINE
CARBAMIC ACID
Trancopal Dolo
FLUPIRITNE MALEATE
N-Acetylated Flupirtine
Ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate
N-[2-Amino-6-[(p-fluorobenzyl)amino]-3-pyridinyl]carbamic acid ethyl ester
[2-Amino-6-[[(4-fluorophenyl)methyllaminol-3-pyridinyl]carbamic acid ethyl ester
Carbamic acid, [2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-, ethyl ester
Carbamic acid, N-[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-, ethyl ester | [EINECS(EC#)]
260-503-8 | [Molecular Formula]
C15H17FN4O2 | [MDL Number]
MFCD00864265 | [MOL File]
56995-20-1.mol | [Molecular Weight]
304.32 |
| Chemical Properties | Back Directory | [Melting point ]
115-116° | [Boiling point ]
445.15°C (rough estimate) | [density ]
1.350±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
12.19±0.70(Predicted) | [Water Solubility ]
1g/L(temperature not stated) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystallizes from isopropanol, melting point 115-116°C. A 5% ethanol solution is colorless but turns green after 20 hours of exposure to air. Acute toxicity LD50: 617 in mice and 1660 in rats (mg/kg) orally. Flupirtine Hydrochloride: C????H????FN??O??·HCl. Crystallizes from water, melting point 214-215°C. Flupirtine Maleate: C????H????FN??O??·C????H??O??. [75507-68-5]. Obtained as colorless crystals from isopropanol, melting point 175.5-176°C. A mixture of crystals A and B; preferably containing 60%-90% A. | [Uses]
Analgesic. | [Uses]
Therapeutic use of Flupirtine was discontinued due to drug induced liver injury (DILI). Since the mechanism of action is not related to its adverse effects, it is important to focus on chemical modifications. | [Definition]
ChEBI: N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester is an aminopyridine. | [Clinical Use]
Flupirtine maleate is an
analgesic with an unknown mode of action. It is
used in single doses of 100 mg orally and 150
mg rectally for the treatment of different pain
conditions. |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|