| Identification | Back Directory | [Name]
5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE | [CAS]
57054-92-9 | [Synonyms]
5-BroMo-2-chloro-4-Methox...
2-chloro-5-broMo-4-MethoxypyriMidine
5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE
Pyrimidine, 5-bromo-2-chloro-4-methoxy-
5-Bromo-2-chloro-4-methoxypyrimidine, >=98%
5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH
5-Bromo-2-chloro-4-methoxy-1,3-diazine, 5-Bromo-2-chloropyrimidin-4-yl methyl ether | [Molecular Formula]
C5H4BrClN2O | [MDL Number]
MFCD03001373 | [MOL File]
57054-92-9.mol | [Molecular Weight]
223.46 |
| Chemical Properties | Back Directory | [Melting point ]
73-75 °C(Solv: hexane (110-54-3)) | [Boiling point ]
323.6±22.0 °C(Predicted) | [density ]
1.745±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml; Ethanol: 15 mg/ml | [form ]
A crystalline solid | [pka]
-1.35±0.29(Predicted) |
| Hazard Information | Back Directory | [Description]
5-bromo-2-chloro-4-Methoxypyrimidine is a building block used in the chemical synthesis of halogenated heterocycles. | [Uses]
5-Bromo-2-chloro-4-methoxypyrimidine is a building block in the chemical synthesis. | [Synthesis]
To a stirred solution of 5-bromo-2,4-dichloropyrimidine (500 mg, 2.19 mmol) in methanol (5 mL) was slowly added 30% sodium methanol solution (0.40 mL, 2.26 mmol). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure. The residue was dissolved in water (5 mL) and extracted with ethyl acetate (3 x 5 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 5-bromo-2-chloro-4-methoxypyrimidine (432 mg, 88% yield) as a white solid.LCMS-ESI (m/z): C5H4BrClN2O Calculated value: 223.4; Measured value: 224.2 [M + H]+, tR = 7.66 min (Method 2) The following is a summary of the results. | [References]
[1] Patent: WO2011/76419, 2011, A1. Location in patent: Page/Page column 119
[2] Patent: EP2338888, 2011, A1. Location in patent: Paragraph 0173; 0174
[3] Tetrahedron Letters, 2006, vol. 47, # 26, p. 4415 - 4418
[4] Patent: CN106588884, 2017, A. Location in patent: Paragraph 0299; 0303; 0304; 0305
[5] Patent: WO2013/90454, 2013, A2. Location in patent: Paragraph 00386 |
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