| Hazard Information | Back Directory | [Description]
Bts 39542 is a diuretic. The ratio of the excretion of the major cations (sodium plus potassium) to that of the major anion (chloride) after BTS 39542 varied with species. In dogs, Bts 39542 exerts its major effects in the loop of Henle and increases renal blood flow but does not affect glomerular filtration rate. | [Uses]
BTS 39542 is an orally active inhibitor for Na+ K+ Cl cotransport system, that exhibits diuretic activity, and can be used in hypertension and edema research[1]. | [References]
[1] Aiton JF, et al., Diuretic action of BTS 39542 (dihydrophthalazin-1-ylacetic acid) is consistent with inhibition of Na + K + Cl cotransport. Biochem Pharmacol. 1982 Sep 1;31(17):2827-30. DOI:10.1016/0006-2952(82)90142-3 |
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