| Identification | Back Directory | [Name]
Flecainide hydrochloride | [CAS]
57415-44-8 | [Synonyms]
Flecainide hydrochloride
N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide hydrochloride | [Molecular Formula]
C17H21ClF6N2O3 | [MDL Number]
MFCD19982476 | [MOL File]
57415-44-8.mol | [Molecular Weight]
450.81 |
| Hazard Information | Back Directory | [Uses]
Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT)[1][2][3]. | [Biological Activity]
Flecainide hydrochloride is a potent and orally active antiarrhythmic agent. Flecainide hydrochloride blocks the cardiac fast inward Na+ current (INa) and the rapid component of the delayed rectifier K+ current. Flecainide hydrochloride prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide hydrochloride has the potential for the research of fetal tachycardias[1][2][3]. | [in vivo]
Flecainide (hydrochloride) (20 mg/kg; intraperitoneal injection; single dose) completely inhibits catecholamine-induced ventricular arrhythmias in Casq2 knockout mice[2]. | [References]
[1]. Echt DS, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991 Mar 21;324(12):781-8.[2]. Aliot E, et al. Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation. Europace. 2011 Feb;13(2):161-73.[3]. Allan LD, et al. Flecainide in the treatment of fetal tachycardias. Br Heart J. 1991 Jan;65(1):46-8. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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