| Identification | Back Directory | [Name]
Ketoprofen lysinate | [CAS]
57469-78-0 | [Synonyms]
Lysine salt
Lysyl-ketoprofen
ketoprofen lysine
Ketoprofen lysinate
Ketoprofen lysine salt
Ketoprofen lysinate USP/EP/BP
2-(3-Benzoylphenyl)propanoic acid lysine salt
2-(3-benzoylphenyl)propanoic acid: (2R)-2,6-diaminohexanoic acid | [Molecular Formula]
C22H28N2O5 | [MDL Number]
MFCD03701078 | [MOL File]
57469-78-0.mol | [Molecular Weight]
400.47 |
| Hazard Information | Back Directory | [Uses]
Ketoprofen Lysinate is a non-steroidal anti-inflammatory drug used in the symptomatic treatment of some chronic inflammatory diseases. An anti-inflammatory agent. | [in vivo]
Ketoprofen lysinate (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%)[2].
Ketoprofen lysinate (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS[3]. | Animal Model: | HFD-induced obese C57BL/6 mice[2] | | Dosage: | 10 mg/kg | | Administration: | Oral administration, three times a week for 10 weeks | | Result: | Decreased in relative body weight, the iWAT mass, and the level of leptin and resistin. |
| Animal Model: | LPS (0.2 μg/mL)-treated dairy cows [3] | | Dosage: | 50 mg/kg | | Administration: | Injection (Milk samples were taken every 30 min until 6 and 9 h) | | Result: | Lowered the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk. |
| [IC 50]
COX-1: 2 nM (IC50); COX-2: 26 nM (IC50) |
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