| Identification | Back Directory | [Name]
ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride | [CAS]
57530-40-2 | [Synonyms]
NIK-244
Ethacizin
Ethacizin hydrochloride
ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride | [Molecular Formula]
C22H28ClN3O3S | [MDL Number]
MFCD00347719 | [MOL File]
57530-40-2.mol |
| Hazard Information | Back Directory | [Uses]
Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than?Flecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2]. | [in vivo]
NIK-244 (1-300 ug) injects directly into the SA node and PM preparations shows negative chronotropic, negative inotropic and coronary vasodilator[1]. | [References]
[1] Sugiyama A, et al. Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.Jpn J Pharmacol. 1991 May;56(1):1-12. DOI:10.1254/jjp.56.1
[2] Satoh H, et al. An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle.Br J Pharmacol. 1989 Nov;98(3):827-32.Med Chem.?2019 Nov 6:115132. DOI:10.1111/j.1476-5381.1989.tb14611.x |
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