| Identification | Back Directory | [Name]
(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER | [CAS]
57561-39-4 | [Synonyms]
AKOS 92083
N-Boc-N-meth
BOC,ME-N-ET-OH
Boc,Me-Glycinol
Boc-N-Me-Gly-OL
BOC-N-ME-AMINOETHANOL
N-Methyl N-Boc-ethanolaMine
N-BOC-N-METHYL-ETHANOLAMINE
N-Boc-N-methyl-aminoethanol
2-(N-BOC-METHYLAMINO)ETHANOL
N-Boc-N-methyl-2-aminoethanol
N-Boc-N-methylethanolamine,95%
2-(N-Boc-N-methylamino)ethanol
2-(N-METHYL-N-BOC-AMINO)ETHANOL
TERT-BUTYL N-(2-HYDROXYETHYL)-N-M
(2-hydroxyethyl)MethylcabaMic acid
(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1
2-(Methylamino)ethanol, N-BOC protected
N-(tert-Butoxycarbonyl)-N-methylglycinol
tert-Butyl 2-hydroxyethyl(methyl)carbamate
N-T-BUTYLOXYCARBONYL-N-METHYL-AMINOETHANOL
N-(TERT-BUTOXYCARBONYL)-N-METHYLETHANOLAMINE
2-(Methylamino)ethanol, N-BOC protected 97%
Ethanolamine, N-(t-butoxycarbonyl)-N-methyl-
N-TERT-BUTYLOXYCARBONYL-N-METHYL-AMINOETHANOL
TERT-BUTYL N-(2-HYDROXYETHYL)-N-METHYLCARBAMATE
N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol
methyl(2-hydroxyethyl)carbamic acid tert-butyl ester
(2-HYDROXY-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER
N-Methyl-N-(2-hydroxyethyl)carbamic acid tert-butyl ester
N-(2-hydroxyethyl)-N-methylcarbamic acid tert-butyl ester
N-(2-hydroxyethyl)-N-methyl-carbamic acid tert-butyl ester
(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
Carbamic acid, N-(2-hydroxyethyl)-N-methyl-, 1,1-dimethylethyl ester
N-t-Butyloxycarbonyl-N-methyl-aminoethanol, N-t-Butyloxycarbonyl-N-methyl-glycinol
tert-Butyl (2-hydroxyethyl)methylcarbamate, N-(tert-Butoxycarbonyl)-N-methylglycinol | [Molecular Formula]
C8H17NO3 | [MDL Number]
MFCD03425857 | [MOL File]
57561-39-4.mol | [Molecular Weight]
175.23 |
| Chemical Properties | Back Directory | [Boiling point ]
120-126°C 4mm | [density ]
1.037±0.06 g/cm3(Predicted) | [refractive index ]
1.4410 to 1.4460 | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
14.67±0.10(Predicted) | [color ]
Colorless to pale yellow | [Water Solubility ]
Soluble in diochloromethane. Slightly soluble in water. | [InChI]
InChI=1S/C8H17NO3/c1-8(2,3)12-7(11)9(4)5-6-10/h10H,5-6H2,1-4H3 | [InChIKey]
RFDSJHHLGFFVHD-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)N(CCO)C |
| Hazard Information | Back Directory | [Uses]
N-Boc-N-methylethanolamine is an substituent in the synthesis of anticancer agent, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription. | [Synthesis]
General procedure: To a solution of 2-(methylamino)ethanol (500 mg, 0.53 mL, 6.66 mmol) in dichloromethane (20 mL) was added di-tert-butyl dicarbonate (1.48 g, 6.79 mmol), and the reaction was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was extracted with saturated aqueous sodium chloride solution and dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give N-BOC-N-methylaminoethanol (colorless oil, quantitative yield). The product was characterized as follows: 1H NMR (200 MHz, CDCl3) δ 3.74 (q, J = 10.5, 5.2 Hz, 2H), 3.25 (t, J = 5.2 Hz, 2H), 2.91 (s, 3H), 1.45 (s, 9H); mass spectra m/z (relative intensities) 144 (20), 102 (24), 57 (70), 44 (100). | [References]
[1] Journal of Organic Chemistry, 2000, vol. 65, # 20, p. 6368 - 6380
[2] Patent: US2009/42872, 2009, A1. Location in patent: Page/Page column 19
[3] Patent: US2007/4675, 2007, A1. Location in patent: Page/Page column 92-93
[4] Patent: WO2007/81091, 2007, A1. Location in patent: Page/Page column 26
[5] Patent: WO2011/5028, 2011, A2. Location in patent: Page/Page column 11 |
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