| Identification | Back Directory | [Name]
GAMMA-ACETYLENIC GABA | [CAS]
57659-38-8 | [Synonyms]
RMI-71645
γ-Acetylenic GABA
GAMMA-ACETYLENIC GABA
4-amino-5-hexynoicaci
4-AMINO-5-HEXYNOIC ACID
5-Hexynoic acid, 4-amino- | [Molecular Formula]
C6H9NO2 | [MDL Number]
MFCD00468056 | [MOL File]
57659-38-8.mol | [Molecular Weight]
127.14 |
| Chemical Properties | Back Directory | [Boiling point ]
291.1±30.0 °C(Predicted) | [density ]
1.155±0.06 g/cm3(Predicted) | [solubility ]
H2O: 5 mg/mL | [form ]
solid | [pka]
4.24±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA can increase the concentration of GABA in rat brain[1][2][3]. γ-Acetylenic GABA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
γ-Acetylenic GABA (100 mg/kg i.p.) inhibits GABA-transaminase activity and causes a several-fold increase in the concentration of GABA in rat brain[2]. | [References]
[1] Casey DE, et, al. gamma-Acetylenic GABA in tardive dyskinesia. Arch Gen Psychiatry. 1980 Dec;37(12):1376-9. DOI:10.1001/archpsyc.1980.01780250062007
[2] Palfreyman MG, et, al. The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems. Eur J Pharmacol. 1978 Aug 15;50(4):325-36. DOI:10.1016/0014-2999(78)90138-3
[3] Alabed S, et, al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2011 Apr 13;(4):CD000203. DOI:10.1002/14651858.CD000203.pub3 |
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