| Identification | Back Directory | [Name]
Kansuinine B | [CAS]
57685-46-8 | [Synonyms]
Kansuinin B
Kansuinine B
2H-Cyclopenta[5,6]cyclododec[1,2-b]oxirene-3,11(1aH,4H)-dione, 8,10a-bis(acetyloxy)-5,7-bis(benzoyloxy)decahydro-4,9,10-trihydroxy-2,2,9,12-tetramethyl-6-methylene-, (1aS,4R,5S,7R,7aS,8R,9R,10S,10aS,12S,12aS)- | [Molecular Formula]
C38H42O14 | [MDL Number]
MFCD34469549 | [MOL File]
57685-46-8.mol | [Molecular Weight]
722.73 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, away from moisture | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Kansuinine B shows cytotoxic activity.
Kansuinine B shows analgesic activity.
3. Treatment with kansuinine B and kansuinine A represents a novel method to block the IL-6-induced effects. | [Uses]
Kansuinine B inhibits IL-6-induced Stat3 activation. Kansuinine B possesses anti-viral activity and could be used in the study for COVID-19[1][2][3]. | [Definition]
ChEBI: Kansuinine B is a benzoate ester. | [target]
IL Receptor | STAT | ERK | MEK | [References]
[1] Jong Sun Chang, et al. Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Planta Med. 2010 Oct;76(14):1544-9. DOI:10.1055/s-0030-1249805
[2] Xiaoyun Shu, et al. Bioassay-guided separation of the proinflammatory constituents from the roots of Euphorbia kansui. J Nat Med. 2010 Jan;64(1):98-103. DOI:10.1007/s11418-009-0366-0
[3] YASER DAANIAL , et al. PROMISING COMPOUNDS FOR TREATMENT OF COVID-19. VAWKUM Transactions on Computer Sciences, ISSN(e):2308-8168, ISSN(p): 2411-6335. Volume 17, Number 1, January-June, 2020. |
|
|