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57754-86-6

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57754-86-6 Structure

57754-86-6 Structure
IdentificationBack Directory
[Name]

NISOXETINE HYDROCHLORIDE
[CAS]

57754-86-6
[Synonyms]

LY-94,939
Nsc298819
NisoxetineHCl
NISOXETINE HYDROCHLORIDE
LY-94939; NSC298819; NISOXETINE HCL
4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride
NISOXETINE HYDROCHLORIDE (LY-94,939) NOR PINEPHRINE UPTAKE
(+/-)-g-(2-Methoxyphenoxy)-N-methylbenzenepropanaminehydrochloride
(±)-γ-(2-methoxyphenoxy)-n-methyl-benzenepropanamine hydrochloride
3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine hydrochloride
(+/-)-GAMMA-(2-METHOXYPHENOXY)-N-METHYL-BENZENEPROPANAMINE HYDROCHLORIDE
LY-94,939, (±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride
[Molecular Formula]

C17H22ClNO2
[MDL Number]

MFCD00153850
[MOL File]

57754-86-6.mol
[Molecular Weight]

307.82
Chemical PropertiesBack Directory
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

H2O: 20 mg/mL
[form ]

solid
[color ]

white
[Water Solubility ]

Soluble to 100 mM in water
[InChI]

InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
[InChIKey]

LCEURBZEQJZUPV-UHFFFAOYSA-N
[SMILES]

C(CCNC)(OC1=CC=CC=C1OC)C1C=CC=CC=1.Cl
Safety DataBack Directory
[Safety Statements ]

22-26-36
[WGK Germany ]

3
[RTECS ]

NI2922170
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

Nisoxetine Hydrochloride is a selective and potent inhibitor of norepinephrine transporter.
[Biological Activity]

A potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.
[Biochem/physiol Actions]

Nisoxetine?is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.
[in vivo]

Nisoxetine (2.2 μM; a single intrathecal injection) hydrochloride shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively[3].
Nisoxetine (3,10, 30 mg/kg, i.p.) hydrochloride inhibits refeeding response (intake of standard chow) in rats[4].

Animal Model:Sprague-Dawley rats(290-340 g)[3]
Dosage:0.6, 1.2, 1.8, 2.2 μM
Administration:A single intrathecal injection
Result:Showed ED50s of 0.82, 0.75 and 0.70 μM in blocking motor function, proprioception, and nociception respectively.
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

NISOXETINE HYDROCHLORIDE(57754-86-6)1HNMR
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