| Identification | Back Directory | [Name]
ALBORIXIN | [CAS]
57760-36-8 | [Synonyms]
ALBORIXIN
Antibiotic S-14750A
2H-Pyran-2-acetic acid, 6-[(2R,3S)-3-[(2R,5S,6R)-6-[[(2R,3S,5R,6R)-6-[(R)-[(2S,2'R,3'R,5S,5'S)-5'-[(2R,5R,6S)-6-ethyltetrahydro-5-hydroxy-5-methyl-2H-pyran-2-yl]octahydro-2'-hydroxy-2,3',5'-trimethyl[2,2'-bifuran]-5-yl]hydroxymethyl]tetrahydro-6-hydroxy-3,5-dimethyl-2H-pyran-2-yl]methyl]tetrahydro-6... | [Molecular Formula]
C48H84O14 | [MDL Number]
MFCD01939330 | [MOL File]
57760-36-8.mol | [Molecular Weight]
885.17 |
| Chemical Properties | Back Directory | [Melting point ]
100-105° | [alpha ]
20 -7° (c = 4 in acetone) | [Boiling point ]
929.8±65.0 °C(Predicted) | [density ]
1.157±0.06 g/cm3(Predicted) | [solubility ]
Dichloromethane: Soluble
DMSO: Soluble
Ethanol: Soluble
Methanol: Soluble | [pka]
10.02 (25° in methanol) |
| Hazard Information | Back Directory | [Uses]
Alborixin is an inhibitor of the PI3K-AKT pathway that induces autophagy. It promotes the clearance of intracellular and extracellular amyloid-β by upregulating autophagy-related proteins (such as BECN1, ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease[1]. | [Definition]
ChEBI: A polyether antibiotic that is isolated from cultures of a strain of Streptomyces albus. | [References]
[1] Wani A, et al. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy. 2019 Oct;15(10):1810-1828. DOI:10.1080/15548627.2019.1596476 |
|
|