| Identification | Back Directory | [Name]
glycyl-sarcosyl-sarcosine | [CAS]
57836-11-0 | [Synonyms]
glycyl-sarcosyl-sarcosine
Glycine, glycyl-N-methylglycyl-N-methyl-
2-(2-(2-Amino-N-methylacetamido)-N-methylacetamido)acetic acid | [Molecular Formula]
C8H15N3O4 | [MDL Number]
MFCD00237968 | [MOL File]
57836-11-0.mol | [Molecular Weight]
217.22 |
| Hazard Information | Back Directory | [Uses]
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation[1][2][3]. | [in vivo]
H-Gly-Sar-Sar-OH (0.1 mM; perfusion; single dose) is insignificantly hydrolyzed (administered for 60 min) or cleared in the kidneys of Sprague-Dawley rats[2].
H-Gly-Sar-Sar-OH (10 mg/kg; p.o.; single dose) shows stability in spontaneously hypertensive rats (SHRs)[3].
Pharmacokinetic (PK) parameters of H-Gly-Sar-Sar-OH in SHRs[3]
| Week old | Cmax (nmol/mL, plasma) | Tmax (min) | AUC0-90 min (nmol?min/mL, plasma) | T1/2 (min) | | 8 | 4.6±0.6 | 30 | 258.0±32.1 | 75 | | 40 | 10.7±1.5 | 30 | 621.0±86.3 | 83 |
| Animal Model: | Male Sprague-Dawley rats (350 g)[2]. | | Dosage: | 0.1 mM. | | Administration: | Perfusion (kidney); single dose. | | Result: | Showed stability. |
| Animal Model: | Male SHRs (8 and 40 week-old)[3]. | | Dosage: | 10 mg/kg. | | Administration: | Oral gavage; single dose. | | Result: | Detected in full form. |
| [References]
[1] Hong SM, et al. Structural Design of Oligopeptides for Intestinal Transport Model. J Agric Food Chem. 2016 Mar 16;64(10):2072-9. DOI:10.1021/acs.jafc.6b00279
[2] Minami H, et al. Oligopeptides: mechanism of renal clearance depends on molecular structure. Am J Physiol. 1992 Jul;263(1 Pt 2):F109-15. DOI:10.1152/ajprenal.1992.263.1.F109
[3] Hanh VT, et al. Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats. J Agric Food Chem. 2017 Jul 26;65(29):5935-5943. DOI:10.1021/acs.jafc.7b01727 |
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