| Identification | Back Directory | [Name]
GW806742X | [CAS]
579515-63-2 | [Synonyms]
CS-2659
GW806742X
GW806742X ≥95%
GW806742X >=98% (HPLC)
GW806742X;GW-806742X;GW 806742X
1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea
Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]- | [Molecular Formula]
C25H22F3N7O4S | [MDL Number]
MFCD29036385 | [MOL File]
579515-63-2.mol | [Molecular Weight]
573.55 |
| Chemical Properties | Back Directory | [density ]
1.524±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);174.35(Max Conc. mM) | [form ]
Solid | [pka]
10.09±0.60(Predicted) | [color ]
White to off-white | [InChIKey]
SNRUTMWCDZHKKM-UHFFFAOYSA-N | [SMILES]
CN(C1=NC(NC2=CC(S(=O)(N)=O)=CC=C2)=NC=C1)C3=CC=C(NC(NC4=CC=C(OC(F)(F)F)C=C4)=O)C=C3 |
| Hazard Information | Back Directory | [Uses]
GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2]. | [Biological Activity]
GW806742X, an ATP mimetic, is a potent MLKL inhibitor that binds the MLKL pseudokinase domain with a Kd of 9.3μM. It has anti-VEGFR2 activity (IC50=2 nM). It delays MLKL membrane translocation and inhibits necrosis. | [in vitro]
GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD -OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM. | [target]
| MLKL 9.3 μM (Kd) | VEGFR2 2 nM (IC 50 < /sub> ) | | [IC 50]
MLKL: 9.3 μM (Kd); VEGFR2: 2 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Hildebrand JM, et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. DOI:10.1073/pnas.1408987111
[2] Sammond DM, et al. Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase. Bioorg Med Chem Lett. 2005;15(15):3519-3523. DOI:10.1016/j.bmcl.2005.05.096 |
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