| Identification | Back Directory | [Name]
PUROMYCIN AMINONUCLEOSIDE | [CAS]
58-60-6 | [Synonyms]
Nsc3056
Aids000507
Aids-000507
aminonucleoside
3′-Amino-3′-deoxy-N6
aminonucleosidepuromycin
PuroMycin aMinonucleosid
stylomycinaminonucleoside
PUROMYCIN AMINONUCLEOSIDE
puromycin aminonucleoside (PAN)
3'-DiMethylaMino-3'-deoxyadenosine
PUROMYCIN AMINONUCLEOSIDE USP/EP/BP
3’-amino-3’-deoxy-n,n-dimethyl-adenosin
3'-AMINO-3'-DEOXY-N,N-DIMETHYL-ADENOSINE
3'-AMINO-3'-DEOXY-N6,N6-DIMETHYLADENOSINE
Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl-
Puromycin aminonucleoside Ready Made Solution
6-DIMETHYLAMIN-9-[3'-AMINO-3'DEOXYRIBOSYL]-PURINE
6-(dimethylamino)-9-(3-amino-3-deoxy-beta-d-ribofuranosyl)purine
9-(3-amino-3-deoxy-beta-d-ribofuranosyl)-6-(dimethylamino)-9h-purine
9-(3-Amino-3-deoxy-.beta.-D-ribofuranosyl)-N,N-dimethyl-9H-purin-6-amine
Puromycin Aminonucleoside, 6-Dimethylamin-9-[3-amino-3deoxyribosyl]-purine
3’-Amino-3’-deoxy-N6,N6-dimethyladenosine, puromycin aminonucleoside (PAN)
(2R,3R,4S,5S)-4-amino-2-(6-(dimethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol
SAN Puromycin-Amino-Nucleoside NSC 3056 Aminonucleoside puromycin PANS | [EINECS(EC#)]
200-388-3 | [Molecular Formula]
C12H18N6O3 | [MDL Number]
MFCD00063462 | [MOL File]
58-60-6.mol | [Molecular Weight]
294.31 |
| Chemical Properties | Back Directory | [Melting point ]
235℃ (Decomposition) | [Boiling point ]
436.08°C (rough estimate) | [density ]
1.2131 (rough estimate) | [refractive index ]
1.7000 (estimate) | [Fp ]
>110°(230°F) | [storage temp. ]
2-8°C
| [solubility ]
H2O: 50 mg/mL, clear, slightly yellow
| [form ]
liquid | [pka]
13.26±0.70(Predicted) | [color ]
White | [Water Solubility ]
Soluble in water at 50mg/ml. May require heating | [BRN ]
93902 | [Stability:]
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. | [InChIKey]
RYSMHWILUNYBFW-GRIPGOBMSA-N | [EPA Substance Registry System]
Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6) |
| Hazard Information | Back Directory | [Chemical Properties]
White crystal | [Uses]
Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumor properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells. | [Uses]
Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells. | [Definition]
ChEBI: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. | [Description]
Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1?It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo. | [References]
1) Chow et al. (1995), Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis; Exp. Cell Res., 216 149
2) Krishnamurti et al. (2001), Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells; J. Am. Soc. Nephrol., 12 758
3) Egashira et al. (2006), Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis; Int. J. Vitam. Nutr. Res., 76 28
4) Hagiwara et al. (2006), Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis; Kidney Int., 69 1146
5) Lowenborg et al. (2000), Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats; Nephrol. Dial. Transplant, 15 1547 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
48/22 | [WGK Germany ]
3
| [RTECS ]
AU7337000
| [F ]
10-21 | [TSCA ]
Yes | [HS Code ]
29419090 | [Safety Profile]
An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx,. |
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