| Identification | Back Directory | [Name]
SUBEROSIN | [CAS]
581-31-7 | [Synonyms]
Cork zanthoxylin
6-Isopentenyl-7-methoxy-2H-1-benzopyran-2-one
7-methoxy-6-(3-methylbut-2-enyl)chromen-2-one
7-Methoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one
2H-1-Benzopyran-2-one, 7-methoxy-6-(3-methyl-2-buten-1-yl)- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C15H16O3 | [MDL Number]
MFCD00210574 | [MOL File]
581-31-7.mol | [Molecular Weight]
244.29 |
| Chemical Properties | Back Directory | [Melting point ]
87.5 °C(Solv: methanol (67-56-1)) | [Boiling point ]
158-172 °C(Press: 0.05 Torr) | [density ]
1.126±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Cryst. | [color ]
White to off-white | [LogP]
3.870 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
It is soluble in organic solvents such as methanol, ethanol, and DMSO, and is derived from the leaves of Radix Angelicae Pubescentis and Radix Angelicae Pubescentis (the leaves of the Cornus officinalis plant (Cornus officinalis) of the family Cornaceae). | [Uses]
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2]. | [Definition]
ChEBI: A natural product found in Citropsis articulata. | [storage]
4°C, protect from light | [References]
[1] Y-C Chen, et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-jB. British Journal of Pharmacology (2007) 150, 298-312.
[2] Golfakhrabadi F, et al. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52(10):1335-40. DOI:10.3109/13880209.2014.892140 |
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