| Identification | Back Directory | [Name]
N3-PEG4-tBu | [CAS]
581066-04-8 | [Synonyms]
N3-PEG4-tBu
581066-04-8
Azido-PEG4-Boc
Azido-PEG4-COOtBu
N3-PEG4-CH2CH2COOtBu
N3-?PEG4-?t-?butyl ester
Azido-PEG5-t-butyl ester
15-Azido-4,7,10,13-tetraoxapentadecanoic acid 1,1-dimethylethyl ester
N3-PEG4-CH2CH2COOtBu | [Molecular Formula]
C15H29N3O6 | [MDL Number]
MFCD18916988 | [MOL File]
581066-04-8.mol | [Molecular Weight]
347.407 |
| Hazard Information | Back Directory | [Description]
Azido-PEG4-t-butyl ester is a click chemistry linker containing an azide (N3) and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group is reactive toward alkyne, BCN, DBCO via Click Chemistry . The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Azido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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