| Identification | Back Directory | [Name]
Z-VAL-DL-ASP-FLUOROMETHYLKETONE | [CAS]
582316-00-5 | [Synonyms]
Z-VD-FMK
Z-Val-Asp-Fluoromethyl Ketone
Z-VAL-DL-ASP-FLUOROMETHYLKETONE
Z-VAL-ASP-FLUOROMETHYL KETONE;Z-VD-FMK
3-({N-[(Benzyloxy)Carbonyl]-L-Valyl}Amino)-5-Fluoro-4-Oxopentanoic Acid
3-((S)-2-(((Benzyloxy)carbonyl)aMino)-3-MethylbutanaMido)-5-fluoro-4-oxopentanoic acid
Pentanoic acid,5-fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxo- | [Molecular Formula]
C18H23FN2O6 | [MDL Number]
MFCD08457673 | [MOL File]
582316-00-5.mol | [Molecular Weight]
382.38 |
| Chemical Properties | Back Directory | [Boiling point ]
639.8±55.0 °C(Predicted) | [density ]
1.258±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 10 mg/ml | [form ]
A solid | [pka]
3.92±0.19(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MX1013 is a potent, irreversible dipeptide caspase inhibitor vith?antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50?of 30 nM[1]. | [in vivo]
MX1013 is an effective antiapoptotic agent?in vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects[1]. | Animal Model: | Female ND4 Swiss Webster mice (16.5-21 g)[1] | | Dosage: | 0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mm?Tris-HCl, pH 8.0) | | Administration: | Injected i.v. | | Result: | The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kg?dose protected 100% of the mice at the 3 h time point.
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| [IC 50]
Caspase | [storage]
Store at -20°C | [References]
[1] Wu Yang,?et al. MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity. Br J Pharmacol.?2003 Sep;140(2):402-12. DOI:10.1038/sj.bjp.0705450 |
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