58311-53-8

1085528-19-3

58311-53-8

Explosion-proof operation. Synthesis of (S)-3,4-dimethyloxazolidine-2,5-dione: 1 g (6.2 mmol) of the raw material (cas:1085528-19-3) was dissolved in 3 ml of dichloromethane and stirred for 5 min at 20 °C. Subsequently, 500 μl (1.1 eq.) of thionyl chloride was added. The reaction mixture was warmed to 30 °C and maintained at this temperature for 30 min. Upon completion of the reaction, the mixture was concentrated to 1.5 times the original volume and 10 ml of n-heptane was added slowly with continuous stirring. The resulting white solid was cooled to -20°C and stirred at this temperature for 1 hour. The suspension was filtered through a sintered glass funnel and the solid was washed three times with 3 ml of n-heptane. The solid was dried in air for 2 h to give a white acicular product in a yield of 700 mg in 87.4% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz): δ 1.39 (d, J = 7.5 Hz, 3H); 2.83 (s, 3H); 4.40 (q, J = 7.5 Hz, 1H).