| Identification | Back Directory | [Name]
aspidin BB | [CAS]
584-28-1 | [Synonyms]
aspidin BB
2-[[2,6-Dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)-2,5-cyclohexadien-1-one
2,5-Cyclohexadien-1-one, 2-[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)- | [Molecular Formula]
C25H32O8 | [MOL File]
584-28-1.mol | [Molecular Weight]
460.52 |
| Chemical Properties | Back Directory | [Melting point ]
124-125° | [Boiling point ]
661.2±55.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.50±1.00(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells[1][2]. | [Definition]
ChEBI: Aspidin is a carboxylic ester. It is functionally related to a phloroglucinol. | [IC 50]
Bcl-2; Bax; Caspase-3 | [References]
[1] Sun Y, et al. Aspidin BB, a phloroglucinol derivative, induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells. Chem Biol Interact. 2013 Jul 5;204(2):88-97. DOI:10.1016/j.cbi.2013.04.008
[2] Chen NH, et al. Drychampones A-C: Three Meroterpenoids from Dryopteris championii. J Org Chem. 2016 Oct 7;81(19):9443-9448. DOI:10.1021/acs.joc.6b01720 |
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