| Identification | Back Directory | [Name]
Bucumolol | [CAS]
58409-59-9 | [Synonyms]
Bucumolol
dl-Bucumolol
8-[2-Hydroxy-3-(tert-butylamino)propoxy]-5-methylcoumarin
8-[3-(tert-Butylamino)-2-hydroxypropoxy]-5-methylcoumarin
8-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-5-methyl-2H-1-benzopyran-2-one | [Molecular Formula]
C17H23NO4 | [MDL Number]
MFCD00864572 | [MOL File]
58409-59-9.mol | [Molecular Weight]
305.37 |
| Chemical Properties | Back Directory | [Melting point ]
>163° (dec.) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Originator]
Bucumarol,Sankyo,Japan,1982 | [Uses]
Bucumolol is?an antihypertensive agent and a β-adrenoceptor blocker. | [Definition]
ChEBI: Bucumolol is a member of coumarins. | [Manufacturing Process]
A mixture of 3 g of 8-(2-hydroxy-3-chloropropoxy)-5-methyl coumarin, 4.3 g
of t-butylamine and 60 ml of ethanol is heated at 100°C in a sealed tube for
15 hours. The reaction mixture is concentrated under reduced pressure to
dryness. The residue is recrystallized from a mixture of ethanol and ether to
give 2.1 g of the desired product melting at 226° to 228°C (with
decomposition).
In practice it is usually used as hydrochloride. | [Therapeutic Function]
Beta-adrenergic blocker |
|
| Company Name: |
Leancare Ltd.
|
| Tel: |
+33 962096793 |
| Website: |
www.leancare.co.uk |
|