| Identification | Back Directory | [Name]
2-aminomethyl-4-t-butyl-6-iodophenol | [CAS]
58456-91-0 | [Synonyms]
MK-447
2-aminomethyl-4-t-butyl-6-iodophenol
6-Iodo-2-(aminomethyl)-4-tert-butylphenol
2-(aminomethyl)-4-tert-butyl-6-iodophenol
Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodo- | [Molecular Formula]
C11H16INO | [MDL Number]
MFCD18974564 | [MOL File]
58456-91-0.mol | [Molecular Weight]
305.16 |
| Chemical Properties | Back Directory | [Melting point ]
146-146.5 °C (decomp) | [Boiling point ]
306.9±42.0 °C(Predicted) | [density ]
1.552±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
7.30±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins. | [in vivo]
MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs[1]. | [IC 50]
PGI2 | [storage]
Store at -20°C | [References]
[1] Shriver DA, et al. The gastric antisecretory and antiulcer activity of MK-447, an enhancer of prostaglandin synthesis. Life Sci. 1980 Dec 22-29;27(25-26):2483-7. DOI:10.1016/0024-3205(80)90526-3
[2] Harada Y, et al. Acceleration of endogeneous PGI2 generation from isolated rat aortae by MK-447. Jpn J Pharmacol. 1981 Oct;31(5):845-8. DOI:10.1254/jjp.31.845 |
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