| Identification | Back Directory | [Name]
rac 3-O-Methyl DOPA-d3 | [CAS]
586954-09-8 | [Synonyms]
L-3-alanine
NSC 122476-d3
3-Methoxytyrosine-d3
rac 3-O-Methyl DOPA-d3
DL-3-O-(Methyl-d3)dopa
[2H3]-3-O-Methyl-L-DOPA
DL-3-(Methoxy-d3)tyrosine
3-(Methoxy-d3)-dl-tyrosine
4-Hydroxy-3-(methoxy-d3)phenylalanine
DL-3-(Methoxy-d3)-4-hydroxyphenylalanine
3-(4-Hydroxy-3-methoxy-d3-phenyl)alanine
Levodopa EP Impurity C-d3 (S-isomer) (3-O-Methyldopa-d3)
(2R)-2-amino-3-[4-hydroxy-3-(trideuteriomethoxy)phenyl]propanoic acid | [Molecular Formula]
C10H13NO4 | [MOL File]
586954-09-8.mol | [Molecular Weight]
211.215 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Aqueous Acid (Slightly), DMSO (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Appearance]
white powder | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
3-O-Methyldopa-d3 (3-OMD isotopic standart), 3-Methoxy-L-tyrosine, is a metabolite of L-dioxyphenylalanine (DOPA, L-DOPA, the drug levadopa), which is formed by the action of catechol-O-methyltransferase (COMT). 3-Methoxy-L-tyrosine competitively inhibits the pharmacodynamics of L-DOPA and dopamine. 3-Methoxy-L-tyrosine is an important marker for screening Parkinson's disease patients taking the drug levadopa. 3-Methoxy-L-tyrosine is also a major biochemical marker of aromatic L-amino acid decarboxylase deficiency (AADC, EC 4.1.1.28), an inborn error of metabolism that affects serotonin and dopamine biosynthesis. | [Uses]
Rac 3-O-Methyl DOPA-d3 is the major labelled metabolite of L-DOPA,a useful marker that can be used to screen for the absense of Aromatic L-amino acid decarboxylase (AADC).
| [Definition]
ChEBI:3-Methoxytyrosine is a tyrosine derivative. | [storage]
Store at -20°C |
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