| Identification | Back Directory | [Name]
Traxanox | [CAS]
58712-69-9 | [Synonyms]
Traxanox
5H-[1]Benzopyrano[2,3-b]pyridin-5-one, 9-chloro-7-(2H-tetrazol-5-yl)- | [Molecular Formula]
C13H6ClN5O2 | [MDL Number]
MFCD00864637 | [MOL File]
58712-69-9.mol | [Molecular Weight]
299.67 |
| Hazard Information | Back Directory | [Uses]
Traxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro.
Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase
activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats. | [Definition]
ChEBI: Traxanox is a pyridochromene. | [References]
[1] [Effect of traxanox sodium on inflammatory response] DOI:10.1254/fpj.86.329
[2] Goto K, et al. Inhibitory effect of traxanox sodium on IgE-mediated histamine release from passively-sensitized mast cells of the rat in vitro. Int Arch Allergy Appl Immunol. 1982;68(4):332-337. DOI:10.1159/000233122
[3] Ikegami K, et al. The effects of traxanox sodium of cyclic AMP phosphodiesterase and the concentration of cyclic AMP in the plasma of rats. Chem Pharm Bull (Tokyo). 1983 Feb;31(2):752-5. DOI:10.1248/cpb.31.752 |
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