| Identification | Back Directory | [Name]
Ambruticin | [CAS]
58857-02-6 | [Synonyms]
W7783
W-7783
W 7783
Ambruticin
(+)-ambruticin S
L-gluco-Non-8-enonic acid, 3,7-anhydro-2,4,8,9-tetradeoxy-9-[(1S,2S,3R)-2-[(1E,3R,4E)-5-[(2R,6R)-6-ethyl-3,6-dihydro-5-methyl-2H-pyran-2-yl]-3-methyl-1,4-hexadien-1-yl]-3-methylcyclopropyl]-, (8E)- | [Molecular Formula]
C28H42O6 | [MDL Number]
MFCD00865607 | [MOL File]
58857-02-6.mol | [Molecular Weight]
474.634 |
| Hazard Information | Back Directory | [Originator]
Ambruticin,Universitet
Karlsruhe (TH) | [Uses]
Antifungal. | [Therapeutic Function]
Antifungal | [in vivo]
The acute LD50 values for the sodium salt of Ambruticin in mice were: intravenous 315 mg/kg, oral > 1000 mg/kg[1].
Ambruticin is rapidly absorbed by the oral route in mice. Ambruticin (75 mg/kg, gavage) produces a peak serum level of 46 μg/mL with a serum half-life of 3.1 h[2].
Ambruticin (40 mg/kg, oral, twice daily for a total of 10 days) shows protective activity in Guinea pigs infected with a severe T. mentagrophytes challenge[2].
Ambruticin shows protective activity in mice acutely infected with a severe C. albicans challenge[2].
| Animal Model: | Guinea pigs (infected with a strain of T. mentagrophytes)[2] | | Dosage: | 40 mg/kg | | Administration: | Oral, starting on day 3 postinfection, twice daily for a total of 10 days | | Result: | On postinfection day 15, the guinea pig mean lesion score was approximately 1.3; by postinfection day 27, all the lesions were essentially healed. |
|
|
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|