| Identification | Back Directory | [Name]
13,14-DIHYDROPROSTAGLANDIN E1 | [CAS]
58962-34-8 | [Synonyms]
6-Keto Prostaglandin
6-Oxo-prostaglandin F1α
6-KETOPROSTAGLANDIN F1A
6-oxo-prostaglandin F1alpha
KFGOFTHODYBSGM-ZUNNJUQCSA-N
6-Keto-PGF1alpha
6-Keto-Prostaglandin F1-alfa
6-KETO-PROSTAGLANDIN F1ALPHA
Epoprostenol Related CoMpound A
6-Keto-Prostaglandin F1-alfa-d5
PROSTAGLANDIN F1-ALPHA, 6-KETO-
6-Ketoprostaglandin F1alpha
6-keto Prostaglandin F1 MaxSpecStandard
6-KETO-PROSTAGLANDIN F1ALPHA EIA STANDARD
6-keto Prostaglandin F1α MaxSpec? Standard
6-keto Prostaglandin F1α Lipid Maps MS Standard
6-OXO-9ALPHA,11ALPHA,15S-TRIHYDROXY-PROST-13E-EN-1-OIC ACID
(9α,11α,13e,15s)-9,11,15-trihydroxy-6-oxoprosta-13-en-1-oic acid
Prost-13-en-1-oic acid, 9,11,15-trihydroxy-6-oxo-, (9α,11α,13E,15S)-
(9alpha,11alpha,13E,15S)-9,11,15-Trihydroxy-6-oxoprost-13-en-1-oic acid
6-Oxo-prostaglandin F1α, (9α,11α,13E,15S)-9,11,15-Trihydroxy-6-oxoprosta-13-en-1-oic acid
7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]-6-oxoheptanoic acid
Epoprostenol Related Compound A (7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(S,E)-3-hydroxyoct-1-enyl]cyclop (1237611) | [Molecular Formula]
C20H34O6 | [MDL Number]
MFCD00135222 | [MOL File]
58962-34-8.mol | [Molecular Weight]
370.48 |
| Chemical Properties | Back Directory | [Boiling point ]
575.3±50.0 °C(Predicted) | [density ]
1.191±0.06 g/cm3(Predicted) | [RTECS ]
UK8428300 | [storage temp. ]
−20°C | [solubility ]
ethanol: 10 mg/mL, clear, faintly yellow | [form ]
White to off-white solid. | [pka]
4.69±0.10(Predicted) | [color ]
White to off-white | [BRN ]
2821925 |
| Hazard Information | Back Directory | [Description]
6-keto prostaglandin F1α (6-keto PGF1α) is the inactive, non-enzymatic hydrolysis product of PGI2. 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo. When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α. | [Uses]
6-Ketoprostaglandin F1α is the stable hydrolysis product of prostacyclin (P839060), an eicosanoid which prevents the formation of platelet plugs and an effective vasodilator. | [Definition]
ChEBI: A prostaglandin Falpha that is prostaglandin F1alpha bearing a keto substituent at the 6-position. | [IC 50]
Human Endogenous Metabolite | [References]
[1] PACE-ASCIAK C. Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1.alpha. in the rat stomach[J]. Journal of the American Chemical Society, 1976, 98 8: 2348-2349. DOI: 10.1021/ja00424a065
[2] ROY A. JOHNSON. The chemical structure of prostaglandin X (prostacyclin)[J]. Prostaglandins, 1976, 12 6: Pages 915-928. DOI: 10.1016/0090-6980(76)90126-x
[3] A R BRASH. Metabolic disposition of prostacyclin in humans.[J]. Journal of Pharmacology and Experimental Therapeutics, 1983, 226 1: 78-87.
[4] MALARVIZHI GURUSAMY. Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice.[J]. Journal of Translational Medicine, 2021: 340. DOI: 10.1186/s12967-021-03016-9 |
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