| Identification | Back Directory | [Name]
Disulergine | [CAS]
59032-40-5 | [Synonyms]
CH 29717
CM 29717
Sulergine
Disulergine
N,N-Dimethyl-N'-(6-methylergolin-8α-yl)sulfamide
N,N-Dimethyl-N'-[(8α)-6-methylergolin-8-yl]sulfamide
Sulfamide, N,N-dimethyl-N'-[(8α)-6-methylergolin-8-yl]- | [Molecular Formula]
C17H24N4O2S | [MDL Number]
MFCD00867885 | [MOL File]
59032-40-5.mol | [Molecular Weight]
348.469 |
| Hazard Information | Back Directory | [Uses]
Disulergine (CH 29-717) is an ergot alkaloid. Disulergine is a dopamine receptor agonist. Disulergine inhibits secretion of prolactin in rats. Disulergine inhibits growth hormone (GH) release[1][2][3]. | [References]
[1] Spada A, et al. Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas. J Clin Endocrinol Metab. 1994 Feb;78(2):411-7. DOI:10.1210/jcem.78.2.7906281
[2] Markó M. Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines. Eur J Pharmacol. 1984 Jun 1;101(3-4):263-6. DOI:10.1016/0014-2999(84)90167-5
[3] Spada A, et al. In vitro effect of dopamine on growth hormone (GH) release from human GH-secreting pituitary adenomas. J Clin Endocrinol Metab. 1982 Oct;55(4):734-40. DOI:10.1210/jcem-55-4-734 |
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